Investigation of the molecular mechanism of metformin

Much current research is focused on insulin resistance and how it might be reversed where current treatments are ineffective. The best treatment for insulin-resistant Type 2 diabetes (T2D) is metformin but the target of this drug is still unclear, hampering development of improved agents to support metformin, which is not effective in all T2D and loses potency with prolonged use. In the studentship we will use some chemical tools to study metformin action using a variety of techniques including western blotting, gene expression analysis, enzyme assays, Seahorse and microscopy. A more robust understanding of metformin action will provide the platform to enable future testing of compounds to support metformin use in the clinic.

 1. Logie, L., Harthill, J., Patel, K., Bacon, S. Hamilton, D.L., Macrae, K., McDougall, G., Wang, H-H, Xue, L.,  Jiang, H., Sakamoto, K., Prescott, A.R.,Rena, G. Cellular responses to the metal-binding properties of metformin.  (2012) Diabetes, 61 1423-1433

2. Rena, G. Pearson E.R. and Sakamoto K. (2012) Molecular action and pharmacogenetics of metformin, Diabetes Management 2, 439-452

Supervisor: 
Dr Graham Rena
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