Palmitoylation and the regulation of the “funny” current HCN4 channel

Applications are invited for a PhD studentship in the laboratories of Dr Will Fuller (Division of Molecular & Clinical Medicine, University of Dundee) and Professor Jules Hancox (School of Physiology and Pharmacology and Neuroscience, University of Bristol). The project will characterise a novel regulatory mechanism of the ion channel ‘HCN4’, which controls the rate of the heart’s intrinsic pacemaker. The project will therefore provide new insights into a hitherto overlooked mechanism by which cardiac pacemaker activity could be modulated. Years 1 and 3 of this project will be under the supervision of Dr Fuller in Dundee, and year 2 under the supervision of Professor Hancox in Bristol. 
 
There are excellent opportunities for training in the multi-disciplinary research labs of Dr Fuller and Professor Hancox. The successful applicant will be trained in a variety of standard and state-of-the-art laboratory techniques, including purification of palmitoylated proteins by resin-assisted capture, affinity chromatography to purify proteins from complex mixtures, site directed mutagenesis, density gradient centrifugation to purify lipid rafts, whole-cell voltage clamp experiments and their analysis, SA node dissection, gene silencing, and a variety of cellular imaging and subcellular fractionation techniques. 
 
The anticipated start date for this project is summer 2017.Applications are invited from both current final year undergraduates and graduates. 
 
Division of Molecular & Clinical Medicine, Medical School, Dundee 
The successful applicant will join a thriving research laboratory and have the opportunity to work in an exciting and collaborative research environment, equipped to the highest international standards. The University of Dundee is a leading institution for biomedical research and offers a vibrant research environment with world-leading facilities. Research in the School of Medicine is focused on understanding and combating disease and was given the top rating for its clinical impact at REF2014. 
 
School of Physiology and Pharmacology and Neuroscience, University of Bristol 
The successful applicant will conduct electrophysiology experiments investigating HCN4 function at the University of Bristol, a leading UK research intensive university. The University of Bristol has a strong cardiovascular community dedicated to basic, translational and clinical research. The appointee will join a lively and experienced research team focused on cardiac electrophysiology, based in dedicated Cardiovascular Research Laboratories in the Faculty of Biomedical Sciences. 
 
We welcome informal enquiries to Dr Will Fuller  or Professor Jules Hancox  . Please apply by sending a cover letter, CV and details of two academic referees to Dr Will Fuller. Closing date March 31. 
 
Funding Notes
This project is funded by a 3 year non-clinical PhD studentship from the British Heart Foundation. Entry requirements: Awarded or expected 1st class or high upper 2nd class BSc degree, or MSc with merit or distinction. Funding restricted to UK/EEA nationals. 

 

Supervisor: 
Dr Will Fuller & Prof Jules Hancox
Subject Area: 
View all PhD opportunities in Division: 
School: 
Stipend level (if applicable): 

First year stipend rate £19,919.

Application Closing Date: 
Friday, March 31, 2017