Why does Glucophage (metformin) help some people with diabetes?

Much current research is focused on insulin resistance and how it might be reversed where current treatments are ineffective. The best treatment for insulin-resistant T2D is metformin but the target of this drug is still unclear, hampering development of improved agents to replace metformin, which is not effective in all T2DM and loses potency with prolonged use. In the studentship we will use some chemical tools to study metformin action using a variety of techniques including western blotting, gene expression analysis, microscopy and animal studies. A more robust understanding of metformin action will provide the platform to enable future testing of compounds to support metformin use in the clinic.

Supervisor: 
Dr Graham Rena
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