Biochemistry

The spatio-temporal dynamics of induction of the Keap1/Nrf2 pathway

Multicellular organisms are equipped with elaborate networks of cytoprotective proteins (e.g., glutathione transferases, NAD(P)H: quinone oxidoreductase 1, heme oxygenase 1) that defend against the damaging effects of oxidants and electrophiles, the principal contributors to the pathogenesis of chronic diseases. Under basal conditions, these genes whose transcription is dependent on transcription factor Nrf2, are not expressed at their maximum capacity, but can be upregulated (induced) by a variety of synthetic and natural agents (inducers).

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