Using c-Src inhibitors to improve opioid analgesia

The prevalence of persistent moderate to severe pain is high, affecting 19% of Europeans. While opioids are among the best analgesics for severe pain their prolonged use is compromised by tolerance, which leads to reduced potency and a requirement for escalating doses to maintain adequate pain control. Pain management is also compromised by the major opioid side effects: constipation and respiratory depression.

Personalised medicine for blood pressure and diabetes control and prevention of kidney disease.

The main reason for kidneys to fail is due to diabetes and prolonged exposure to high blood pressure.  These two factors account for nearly three quarters of all kidney disease.   The effectiveness of drugs in the management of blood pressure and diabetes is highly variable in different individuals and it would be desirable to be able to use simple tests to predict which drugs will work in particular patients.   The current project aims to define predictive markers to allow for the more effective prevention of kidney disease in patients with high blood pressure and diabetes.  The student wi

Personalised Medicine in Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is now regarded as the most common liver condition in the developed world, affecting up 30% of the general population. It is closely linked with the metabolic syndrome and its component parts including obesity, type 2 diabetes mellitus (T2DM) and dyslipidaemia, with insulin resistance and excess oxidative stress being the common uniting pathological mechanisms.

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